Book Description

Review 'Computational Toxicology is big and it is clever!...The book is easy to read with a wealth of easy to follow figures and an abundance of references?it offers readers a good perspective of what is currently achievable with computational toxicology and what is on the horizon. This book certainly has a place in most libraries.'--btsNews, June 2014 'This collection reviews the state of the science in computer models for assessing human risk from chemical exposure and identifies specific applications that have enhanced the response to a defined risk assessment challenge?Practical translation of computational methods for risk assessment, computational translation and integration of test data to meet risk assessment goals, and computational translation of data from nonmammalian species? are also discussed.', February 2014 'ICF International experts authored this essential reference on the translation of computational toxicology data into information that can be used for more informed risk-assessment decision making. The book provides an updated summary of the state-of-the-art science in the field of computational toxicology methods and offers examples of applications to risk assessment.'--ICF International online, 2013 'This collection reviews the state of the science in computer models for assessing human risk from chemical exposure and identifies specific applications that have enhanced the response to a defined risk assessment challenge. The 11 contributions describe physiologically based pharmacokinetic?models for simulating dose metrics in sensitive subpopulations, a dynamic systems model of rat liver homeostasis, the quantitative structure-activity relationship? tool for simulating necessary endpoints, and omics biomarker discovery.'--Reference & Research Book News, December 2013 ?The new book on Computational Toxicology edited by Dr. Bruce Fowler is a timely publication.? It presents, in a well-organized and concise manner, a collection of excellent chapters on the methods and practical applications of computational toxicology. This is a very useful reference volume, but can be read cover-to-cover by those of us who want a general and current understanding of computational toxicology.?--James C. Lamb, IV, Ph.D, DABT, ATS Principal Scientists and Center Director Center for Toxicology and Mechanistic Biology Exponent Read more About the Author Dr. Bruce A. Fowler Ph.D., A.T.S is currently a consultant and an Adjunct Professor at Emory University in Atlanta, Georgia, and a Presidents Professor of Biomedical Research at the University of Alaska- Fairbanks. He has previously held positions as a Senior Fellow/Expert Consultant at ICF International, Associate Director for Science in the Division of Toxicology and Environmental Medicine at ATSDR, Director of the System-wide Program in Toxicology at the University of Maryland and Senior Scientist at the NIEHS. He has been previously selected as a Fellow of the Japanese Society for the Promotion of Science (JSPS), Fulbright Scholar and Swedish Medical Research Council Visiting Professor at the Karolinska Institute in Stockholm Sweden. He has chaired and served on a number of national / international committees in the area of metal toxicology including those of the National Academies of Science, WHO, IARC, National Institutes of Health, and USEPA.Dr. Fowler is the author of over 260 research papers and book chapters dealing with molecular mechanisms of metal toxicity and molecular biomarkers for early detection of metal-induced cell injury. He has been the editor or co-editor of 7 books or monographs on metal toxicology, mechanisms of chemical - induced cell injury and computational toxicology. His current research is focused on computational toxicology and the application of molecular biomarkers for risk assessments of chemical mixtures involving metals, particularly in relation to binary semiconductor materials such as gallium arsenide, indium arsenide as well as lead, cadmium, and arsenic mixtures. He has received a number of awards for his research including a Society of Toxicology Colgate-Palmolive Visiting Professorship in In Vitro Toxicology to the University of Washington and CDC National Center for Environmental Health/ATSDR awards including the Honor Award for Excellence in Quantitative Sciences- Cadmium PbPK Modeling Group Award, NCEH/ATSDR Honor Award for Excellence in Emergency Response Deepwater Horizon Oil Spill Response Team (Domestic) Group Award. As a member of the elemental impurities panel, Dr. Fowler has also received the 2014 USP Award for an Innovative Response to Public Health Challenges (Group Award). He serves on the editorial boards of a number of scientific journals in toxicology and is currently an Associate Editor of Environmental Health Perspectives and Toxicology and Applied Pharmacology. Read more